Job Description
The Broad Institute of Harvard and MIT is looking for an exceptional candidate for a unique Research Associate position. This position affords the exciting opportunity to join a team of scientists on genome-scale functional cancer genomics to identify the next generation of cancer therapeutic targets.
OVERALL RESPONSIBILITY
The individual will work with a growing team of scientists dedicated to validate a large number of promising targets emerging from functional genomics screens using cutting-edge technologies including CRISPR and RNAi in in vivo and in vitro models of cancer including patient derived models. The individual will assist a multidisciplinary team of scientists in performing in vivo validation studies
aimed at advancing the nominated targets and will be largely independent on a daily basis after training. The candidate should be familiar with a variety of in vivo handling techniques and skilled in ex vivo cell- and tissue-based assays. The successful candidate is also expected to make intellectual contributions and assist in project planning and experimental design. The individual will interact and collaborate closely with other scientists and will be involved in a series of research activities, including collaborative efforts between research groups, and the verbal and written communication of science.
Principal Duties And Responsibilities
Cell line growth and genetic manipulation.
Assay and reagent development for in vivo screening.
Establishment of tumors (SC, IP, IV, orthotopic).
Tumor growth measurements and monitoring.
Dosing of therapeutics (PO, IP, IV).
Necropsy, blood and tissue collection.
Sample archiving.
Data compilation, analysis and reporting.
Compliance with animal welfare regulations and IACUC protocols.
Requirements
Education
Bachelor or master’s degree in the life sciences.
Prior cell biology and molecular biology coursework.
Experience
Bachelor’s degree with in vivo research experience.
Skills and abilities
Experience with mammalian cells and tissue culture is required.
Mouse handling skills including experience establishing tumor models (SC, IP, IV, orthotopic).
Proficiency with various dosing routes, tissue collection and bleeds desired.
Live animal bioluminescence and fluorescence imaging.
Immunohistochemistry and flow cytometry desired but not required.
Familiarity with molecular biology and protein biochemistry techniques is strongly desired.
Prior experience using lentivirus, CRISPR or RNAi is a plus.
Exceptional organizational and critical thinking skills, lab notebook practices and attention to detail are critically essential.
Excellent communication skills and the ability to interact with all levels of staff and with external contacts are needed.
The Broad Institute provides a vibrant research environment with close links to top academic institutions across the Boston Area, and provides the potential for the associate’s contributions to be used and recognized worldwide.
The Broad Institute will not offer visa sponsorship for this opportunity.
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